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KMID : 1059520160600040245
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Journal of the Korean Chemical Society
2016 Volume.60 No. 4 p.245 ~ p.250
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An Improved Protocol on the Synthesis of Thiazolo[3,2-a]pyrimidine Using Ultrasonic Probe Irradiation
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Tan Sian Hui
Chuah Tse Seng
Chia Poh Wai
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Abstract
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An improved protocol on the synthesis of thiazolo[3,2-a]pyrimidine-6-carboxylate derivatives are reported. Previously, the thiazolo[3,2-a]pyrimidine-6-carboxylate derivatives were prepared in a two-step procedure. Under the improved procedure, the thiazolo[3,2-a]pyrimidine-6-carboxylate derivatives was readily prepared in a one-step reaction. This procedure was found to be more efficient than the previous protocol and also compared to the ultrasound bath and conventional heating methods in terms of yield and reaction time.
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KEYWORD
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One-pot three component synthesis, Thiazolo[3,2-a]pyrimidine, Ultrasound, Solvent- and catalyst-free reaction
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